Myoferlin, a Membrane Protein with Emerging Oncogenic Roles

Table 1

Role of MYOF in specific tumor and its clinical significance.

Cancer type	Expression	Tumor biology	Clinical significance	Reference
Breast cancer	Increased	Increased cell proliferation, migration, invasion, EMT and metastasis	Poor outcome	[55, 56, 60, 65]
Pancreas cancer	Increased	Increased cell proliferation, migration and mitochondrial fitness	Poor prognosis and decreased overall survival	[48, 68, 70]
Lung cancer	Increased	Increased proliferation and angiogenesis	Poorer prognosis	[47, 77]
Liver cancer	Increased	Increased cell growth, invasion and proliferation	Not reported	[74]
Melanoma	Increased	Increased EMT, migration and invasion	Poor prognosis	[78]
Head and neck squamous cell carcinoma	Increased	Increased migration, metastasis	Poor overall survival, tumor recurrence, perineural invasion and distal metastasis	[50, 79]
Follicular lymphoma	Increased	Self-antigenic recognition, BCR-mediated signaling	The patient died	[80]
Endometrioid carcinoma	Decreased	No data	FIGO histologic grading score	[51]
Colon cancer	Increased	Mitochondrial fitness	Low patient survival	[72]
Renal cancer	Increased	No data	Poor patient prognosis. Predication of subsequent primary malignancy	[26, 81]