Review Article
Myoferlin, a Membrane Protein with Emerging Oncogenic Roles
Table 1
Role of MYOF in specific tumor and its clinical significance.
| Cancer type | Expression | Tumor biology | Clinical significance | Reference |
| Breast cancer | Increased | Increased cell proliferation, migration, invasion, EMT and metastasis | Poor outcome | [55, 56, 60, 65] | Pancreas cancer | Increased | Increased cell proliferation, migration and mitochondrial fitness | Poor prognosis and decreased overall survival | [48, 68, 70] | Lung cancer | Increased | Increased proliferation and angiogenesis | Poorer prognosis | [47, 77] | Liver cancer | Increased | Increased cell growth, invasion and proliferation | Not reported | [74] | Melanoma | Increased | Increased EMT, migration and invasion | Poor prognosis | [78] | Head and neck squamous cell carcinoma | Increased | Increased migration, metastasis | Poor overall survival, tumor recurrence, perineural invasion and distal metastasis | [50, 79] | Follicular lymphoma | Increased | Self-antigenic recognition, BCR-mediated signaling | The patient died | [80] | Endometrioid carcinoma | Decreased | No data | FIGO histologic grading score | [51] | Colon cancer | Increased | Mitochondrial fitness | Low patient survival | [72] | Renal cancer | Increased | No data | Poor patient prognosis. Predication of subsequent primary malignancy | [26, 81] |
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