A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats

Figure 2

MRM chromatograms of metoprolol tartrate (1), hydrochlorothiazide (2), nifedipine (3), valsartan (4), and IS (5), (a) blank plasma; (b) blank plasma spiked with the analytes and IS; (c) 1 h plasma sample after oral administration of four antihypertensive drugs, respectively.

(a)

(b)

(c)