A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats

Table 2

Calibration curves, correlation coefficients, linear ranges, and LLOQs of the analytes.

Compounds	Calibration curve	r	Linear range; (ng/mL)	LLOQ; (ng/mL)
metoprolol tartrate	y = 1.1056 x + 0.0057	0.9962	8.0-4000.0	0.1
hydrochlorothiazide	y = 0.0536 x + 0.0012	0.9906	10.0-5000.0	5.0
nifedipine	y = 0.7370 x + 0.0021	0.9924	2.0-1000.0	1.0
valsartan	y = 0.3144 x + 0.0030	0.9958	20.0-10000.0	0.1