BioMed Research International / 2019 / Article / Tab 6 / Research Article
A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats Table 6 Pharmacokinetic parameters of the analytes in different groups (n = 6).
Compounds (ng/mL)t1/2 (h) AUC(0-tn) (h·ng/mL) AUC(0-∞) (h·ng/mL) (h)Ke (1/h) metoprolol tartrate group A 1068.55 ± 330.39 0.84 ± 0.28 1621.21 ± 464.32 1628.06 ± 454.86 0.36 ± 0.15 0.90 ± 0.29 group B 2277.29 ± 240.30 1.06 ± 0.81 3787.97 ± 283.12 3829.12 ± 310.13 0.54 ± 0.25 0.88 ± 0.39 group C 3045.11 ± 424.22 2.16 ± 0.84 5975.49 ± 776.71 6020.93 ± 719.30 0.50 ± 0.00 0.42 ± 0.31 hydrochlorothiazide group A 1515.75 ± 235.11 3.26 ± 0.77 10091.55 ± 1285.15 10756.45 ± 1664.18 1.63 ± 1.24 0.23 ± 0.07 group B 2292.22 ± 209.37 2.68 ± 0.31 10687.69 ± 950.21 11020.65 ± 939.29 0.79 ± 0.19 0.26 ± 0.03 group C 1406.19 ± 248.74 2.52 ± 0.31 8479.60 ± 1243.01 8616.52 ± 1265.25 2.00 ± 0.00 0.28 ± 0.03 nifedipine group A 205.38 ± 73.57 4.45 ± 2.18 1914.09 ± 350.20 2090.41 ± 514.96 3.33 ± 1.03 0.20 ± 0.11 group B 554.60 ± 126.68 2.81 ± 0.85 4217.35 ± 1072.42 4289.90 ± 1100.45 3.33 ± 1.03 0.27 ± 0.08 group C 819.06 ± 146.92 3.12 ± 1.05 5706.47 ± 485.23 5810.56 ± 458.46 2.67 ± 1.51 0.25 ± 0.10 valsartan group A 3669.94 ± 720.62 2.97 ± 1.43 19563.78 ± 9850.62 21861.22 ± 12174.60 0.46 ± 0.29 0.27 ± 0.11 group B 3458.54 ± 324.28 2.47 ± 0.80 15146.64 ± 4814.24 17246.65 ± 6629.68 0.46 ± 0.10 0.31 ± 0.13 group C 4385.92 ± 1246.27 3.40 ± 0.88 20302.97 ± 6783.12 23030.31 ± 7186.54 0.24 ± 0.03 0.21 ± 0.04