Delayed Rectifier K⁺-Channel Is a Novel Therapeutic Target for Interstitial Renal Fibrosis in Rats with Unilateral Ureteral Obstruction

Figure 2

Markers for T-lymphocytes, macrophages, mast cells, and neutrophils expression in the cortical interstitium of UUO rat kidneys. Immunohistochemistry using antibodies for CD3 (a), ED-1 (b) (brown), toluidine blue (TB) staining (c) (blue, arrow heads), and immunohistochemistry for myeloperoxidase (MPO) (d) (brown, arrow heads) in control (A) and UUO rat kidneys with 1 week (UUO-1w, B), 2 weeks (UUO-2w, C), and 3 weeks (UUO-3w, D) after unilateral ureteral obstruction. Magnification: ×60. (e) Numbers of CD3-positive T-lymphocytes, ED-1-positive macrophages, toluidine blue-positive mast cells, and myeloperoxidase-positive neutrophils were counted in high-power views within the cortical interstitium of control, UUO-1w, UUO-2w, and UUO-3w rat kidneys. Values are means ± SEM (n = 5).

(a)

(b)

(c)

(d)

(e)