Delayed Rectifier K⁺-Channel Is a Novel Therapeutic Target for Interstitial Renal Fibrosis in Rats with Unilateral Ureteral Obstruction

Figure 4

Fibrotic marker expression in margatoxin-untreated and margatoxin-treated UUO rat kidneys. (a) Masson’s trichrome staining in margatoxin- (Mgx-) untreated (A) and margatoxin-treated (B) UUO rat kidneys. Low-power views of cortex. Magnification: ×20. (C) Masson’s trichrome deposition was quantified and expressed as percentages of Masson’s trichrome-positive areas relative to the total areas. (b) Immunohistochemistry using an antibody for α-SMA (brown) in margatoxin- (Mgx-) untreated (A) and margatoxin-treated (B) UUO rat kidneys. Magnification: ×20. (C) α-SMA-positive cells were counted in high-power views of the cortical interstitium. versus margatoxin-untreated UUO rats. Values are means ± SEM (n = 5). Differences were analyzed by ANOVA followed by Dunnett’s or Student’s t test.

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