Carvedilol Inhibits Angiotensin II-Induced Proliferation and Contraction in Hepatic Stellate Cells through the RhoA/Rho-Kinase Pathway

Figure 1

(a) HSCs were treated with different concentrations of Ang II and the proliferative effects were evaluated by CCK-8. versus control; versus control. (b) After HSCs were stimulated with Ang II at 1 μM and treated with different concentrations of carvedilol, the proliferative effects were evaluated by CCK-8. versus control; versus Ang II group; versus Ang II group; versus Ang II group; (Ang II + DMSO) group versus Ang II group. (c) Effect of carvedilol on cell cycle progression in HSCs was detected by a muse cell analyzer. (d) Western blot analyses of cell cycle regulatory proteins. versus control; versus control; versus Ang II group; versus Ang II group. Representative blots were obtained from three independent experiments.

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