Carvedilol Inhibits Angiotensin II-Induced Proliferation and Contraction in Hepatic Stellate Cells through the RhoA/Rho-Kinase Pathway

Figure 5

(a–d) HSCs were treated with Ang II (1 μM) and different concentrations of carvedilol. Western blot analyses of collagen I, AT1R, collagen III, RhoA, ROCK2, p-MLC, and MLC. versus control group; versus control group; versus Ang II group; versus Ang II group. (e, f) HSCs were treated with Ang II (1 μM), carvedilol (5 μM), and olmesartan (10 μM). Western blot analyses of collagen I, AT1R, RhoA, and ROCK2. versus control group; versus control group; versus control group; , (Ang II + olmesartan) group versus (Ang II + carvedilol) group, (Ang II + carvedilol + olmesartan) group versus (Ang II + olmesartan) group; , (Ang II + olmesartan) group versus (Ang II + carvedilol) group, (Ang II + carvedilol + olmesartan) group versus (Ang II + olmesartan) group. Representative blots were obtained from three independent experiments.

(a)

(b)

(c)

(d)

(e)

(f)