Carvedilol Inhibits Angiotensin II-Induced Proliferation and Contraction in Hepatic Stellate Cells through the RhoA/Rho-Kinase Pathway

Figure 6

Carvedilol attenuated liver fibrosis in CCl₄-treated mice. (a) H&E staining (magnification ×100). (b) Sirius Red staining (magnification ×100). Collagen deposition was quantified using Image-Pro Plus software. versus oil group; versus CCl₄ group; n = 6. (c) The expression of Fibronectin in liver tissues was detected by immunohistochemistry staining (magnification ×100). versus oil group; versus CCl₄ group; n = 6. (d–f) The expression levels of α-SMA, collagen I, and collagen III in liver tissues were detected by Western blot assay. versus oil group; versus oil group; versus CCl₄ group; versus CCl₄ group. Representative blots were obtained from three independent experiments.

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