Blockage of TGF-α Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells

Figure 3

The expression of cytokines in the THP-1 and/or BEAS-2B. (a) Cytokines detected using a cytokine chip, arrows indicate the TGF-α. (b) TGF-α detected by ELISA in the culture medium of THP-1 cells treated with BPDE and SiNPs. (c) TGF-α mRNA detected by real-time PCR in THP-1 cells treated by SiNPs and BPDE. (d) TGF-α was detected by ELISA in THP-1 or BEAS-2B cells treated by BPDE combined with SiNPs. (e) TGF-α detected in THP-1 or BEAS-2B cells treated by BPDE with or without SiNPs by ELISA. p<0.005.

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