Blockage of TGF-α Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells

<div>Effects of TGF-α and its neutralizing antibodies on the EMT of BEAS-2B cells and tumor growth. (a) The effects of TGF-α (0.4 ng/mL) and anti-TGF-α (1.6 ng/mL) on the proliferation of BEAS-2B cells, control group treated only by BPDE. (b) The colony formation rate of BEAS-2B cells. (c) The growth rate curve of xenografted tumors. (d, e) Ki67, PCNA, and proteins involved EMT in tumor tissue were detected by western blotting. (f) The apoptosis of the tumor tissue was detected using the TUNEL assay, and the markers of EMT in tumor tissue were detected by immunohistochemistry in tumor tissues.</div>

BioMed Research International

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Figure 4: Blockage of TGF-α Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells

Figure 4 | Blockage of TGF-α Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells 