Association of Cystatin C with Metabolic Syndrome and Its Prognostic Performance in Non-ST-Segment Elevation Acute Coronary Syndrome with Preserved Renal Function

Table 4

Summary of ROC curves.

	AUC	95% CI	P value	Cys C cutoff (mg/L)	Sensitivity	Specificity	Youden index
CRP > 5 μg/mL	0.793	(0.749–0.837)	<0.001	0.85	0.782	0.719	0.501
BNP > 100 pg/mL	0.658	(0.605–0.712)	<0.001	1.02	0.464	0.811	0.275
Killip class > 1	0.774	(0.727–0.822)	<0.001	0.93	0.722	0.742	0.465
Multivessel disease	0.887	(0.858–0.919)	<0.001	0.91	0.751	0.887	0.638
SYNTAX score ≥ 23	0.798	(0.741–0.854)	<0.001	0.99	0.754	0.748	0.502
GRACE score ≥ 89	0.781	(0.737–0.826)	<0.001	0.90	0.672	0.786	0.457
MetS	0.627	(0.569–0.685)	<0.001	1.01	0.440	0.757	0.197
MACEs	0.723	(0.664–0.783)	<0.001	0.87	0.816	0.497	0.313
Cardiac death	0.703	(0.595–0.811)	0.006	0.89	0.875	0.485	0.360
Non-fatal MI	0.676	(0.558–0.793)	0.008	1.03	0.550	0.736	0.286
TVR	0.699	(0.609–0.790)	0.001	0.82	0.958	0.369	0.328
Heart failure	0.708	(0.567–0.848)	0.019	0.96	0.727	0.630	0.357

Abbreviations. Cys C: cystatin C; CRP: C-reaction protein; BNP: B-type natriuretic peptide; MetS: metabolic syndrome; MACEs: major adverse cardiovascular events; MI: myocardial infarction; TVR: target vessel revascularization.