Increased COUP-TFII Expression Mediates the Differentiation Imbalance of Bone Marrow-Derived Mesenchymal Stem Cells in Femoral Head Osteonecrosis

<div>Morphological analyses of bone marrow mesenchymal stem cells (BMSCs). (a) Initial primary BMSCs from osteonecrotic patients demonstrated spindle-shaped morphology (magnification, 200x). (b) Following four generations (16 days), the cells presented with a similar spindle morphology (magnification, 200x). (c) Flow cytometry results of mesenchymal stem cells (MSC) showed that the cells were positive for the markers CD90, CD105, and CD73 and negative for CD45/CD34/CD11b/CD19/HLA-DR PE.</div>

BioMed Research International

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Figure 4: Increased COUP-TFII Expression Mediates the Differentiation Imbalance of Bone Marrow-Derived Mesenchymal Stem Cells in Femoral Head Osteonecrosis 

Figure 4 | Increased COUP-TFII Expression Mediates the Differentiation Imbalance of Bone Marrow-Derived Mesenchymal Stem Cells in Femoral Head Osteonecrosis 