Research Article
Optimized Parameters of Diffusion-Weighted MRI for Prediction of the Response to Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer
Table 3
Diagnostic performance of ADC-related parameters.
| | AUC (95% CI) | Cutoff value | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
| Pre-ADC (b = 800) | 0.419 (0.304–0.534) | 0.87 × 10−3 mm2/s | 33 | 41 | 31 | 43 | Post-ADC (b = 800) | 0.692 (0.496–0.724) | 1.01 × 10−3 mm2/s | 41 | 65 | 51 | 64 | ΔADC (b = 800) | 0.879 (0.811–0.946) | 0.232 × 10−3 mm2/s | 79 | 72 | 66 | 53 | Percentage of ADC increase (b = 800) | 0.957 (0.92–0.993) | 29.10% | 87 | 91 | 69 | 76 | Pre-ADC (b = 1000) | 0.411 (0.295–0.527) | 1.03 × 10−3 mm2/s | 41 | 37 | 41 | 45 | Post-ADC (b = 1000) | 0.537 (0.418–0.655) | 1.30 × 10−3 mm2/s | 43 | 64 | 74 | 47 | ΔADC (b = 1000) | 0.866 (0.789–0.942) | 0.335 × 10−3 mm2/s | 74 | 56 | 47 | 69 | Percentage of ADC increase (b = 1000) | 0.893 (0.822–0.965) | 28.67% | 83 | 86 | 51 | 67 |
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CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value.
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