The Possible Pathogenesis of Idiopathic Pulmonary Fibrosis considering MUC5B

Figure 1

Regulation of MUC5B expression in airway epithelial cells. Different stimuli, including some interleukins, ROS, PGD2, and certain bacterial components may induce MUC5B overexpression by MAPKs, STAT3, or STAT6 pathways. The important transcriptional factors including FOXA2, CREB, AP-1, SP1, and NF-κB also directly or indirectly participate in MUC5B overexpression.