A Novel Three-Gene Model Predicts Prognosis and Therapeutic Sensitivity in Esophageal Squamous Cell Carcinoma
Table 1
The clinicopathological characteristics of generation dataset of patients with ESCC.
Clinical and pathological indexes
Case no.
5-year OS (%)
5-year DFS (%)
Specimens
284
Mean age
58.7
Age (year)
≤58
148
48.1
0.036
43.4
0.207
>58
136
39.1
35.8
Gender
Male
220
44.8
0.387
40.5
0.915
Female
64
40.2
37.2
Therapies
Only surgery
160
45.2
0.080
42.0
0.070
Surgery + radiotherapy
39
53.6
51.3
Surgery + chemotherapy
57
46.2
36.4
Surgery + chemoradiotherapy
28
17.9
17.9
Tumor size
≤3 cm
67
55.6
0.057
54.4
0.021
3–5 cm
134
43.5
37.9
>5 cm
83
34.7
31.1
Tumor location
Upper
16
33.5
0.463
25.0
0.127
Middle
122
45.6
44.8
Lower
146
43.3
37.2
Histologic grade
G1
45
57.7
0.001
57.7
<0.001
G2
219
43.5
38.3
G3
20
15.0
15.0
Invasive depth
T1
13
84.6
0.005
84.6
0.013
T2
42
50.0
45.2
T3
229
40.2
36.2
Lymph node metastasis
N0
141
58.1
<0.001
53.5
<0.001
N1
81
44.0
39.0
N2
46
15.2
13.0
N3
16
0.0
0.0
pTNM-stage
I
23
82.6
<0.001
82.6
<0.001
II
131
54.2
49.2
III
130
26.4
22.6
Log-rank test of Kaplan–Meier method; was considered significant. All patients underwent surgical treatment. OS: overall survival. DFS: disease-free survival.
