A Novel Three-Gene Model Predicts Prognosis and Therapeutic Sensitivity in Esophageal Squamous Cell Carcinoma

Table 2

The correlation between 3 markers and clinicopathological characteristics in ESCC.

Variables	MYC^a			PDIA3^b			ITCA5B1^c
	Low	High		Low	High		Low	High
Age (year)
≤58	67	81	0.425	84	64	0.725	92	56	0.334
>58	68	68		80	56		92	44
Gender
Male	109	111	0.208	127	93	0.990	137	83	0.100
Female	26	38		37	27		47	17
Therapies
Only surgery	85	75	0.067	97	63	0.588	107	53	0.849
Surgery + radiotherapy	14	25		20	19		25	14
Surgery + chemotherapy	21	36		30	27		35	22
Surgery + radiochemotherapy	15	13		17	11		17	11
Tumor size
≤3 cm	39	28	0.101	41	26	0.303	43	24	0.489
3–5 cm	62	72		71	63		83	51
>5 cm	34	49		52	31		58	25
Tumor location
Upper	6	10	0.307	9	7	0.383	8	8	0.395
Middle	64	58		65	57		82	40
Lower	65	81		90	56		94	52
Histologic grade
G1	25	20	0.499	20	25	0.054	32	13	0.588
G2	101	118		129	90		140	79
G3	9	11		15	5		12	8
Invasive depth
T1 + T2	32	23	0.078	37	18	0.111	34	21	0.607
T3 + T4	103	126		127	102		150	79
Lymph node metastasis
N0	73	68	0.156	64	77	<0.001	105	36	0.001
N1 + N2 + N3	62	81		100	43		79	64
pTNM-stage
I	17	6	0.011	10	13	0.001	16	7	0.009
II	65	66		64	67		96	35
III	53	77		90	40		72	58

Fisher’s exact test. value < 0.05 was considered significant.