A Novel Three-Gene Model Predicts Prognosis and Therapeutic Sensitivity in Esophageal Squamous Cell Carcinoma
Table 3
Univariate and multivariate analyses of factors associated with overall survival (OS) and disease-free survival (DFS) in patients with ESCC.
Variables
Univariate analysis
Multivariate analysis
OS
DFS
OS
DFS
HR (95% CI)
HR (95% CI)
HR (95% CI)
HR (95% CI)
Age (>58 vs. ≤58)
1.376 (1.017 to 1.861)
0.039
1.203 (0.900 to 1.609)
0.213
1.498 (1.082 to 2.073)
0.015
Gender (female vs. male)
0.857 (0.603 to 1.219)
0.391
0.981 (0.693 to 1.390)
0.916
Therapies
0.090
0.080
(Surgery + radiotherapy vs. only surgery)
0.799 (0.492 to 1.296)
0.363
0.893 (0.557 to 1.432)
0.639
(Surgery + chemotherapy vs. only surgery)
0.918(0.642 to 1.423)
0.825
1.225(0.847 to 1.770)
0.281
(Surgery + radiochemotherapy vs. only surgery)
0.918 (1.036 to 2.550)
0.035
1.701 (1.087 to 2.662)
0.020
Tumor size
0.062
0.025
0.045
0.021
3–5 cm vs. ≤3 cm
1.285 (0.860 to 1.921)
0.222
1.404 (0.948 to 2.077)
0.090
1.378 (0.915 to 2.075)
0.124
1.432 (0.964 to 2.130)
0.076
>5 cm vs. ≤3 cm
1.657 (1.082 to 2.539)
0.020
1.787 (1.176 to 2.716)
0.007
1.730 (1.124 to 2.664)
0.013
1.821 (1.193 to 2.779)
0.005
pTNM-stage (III vs. I + II)
2.087 (1.443 to 3.019)
<0.001
1.956 (1.376 to 2.780)
<0.001
1.876 (1.267 to 2.778)
0.002
1.689 (1.162 to 2.456)
0.006
MYC
1.415 (1.043 to 1.920)
0.026
1.397 (1.041 to 1.874)
0.026
PDIA3
0.618 (0.450 to 0.848)
0.003
0.638 (0.471 to 0.864)
0.004
ITGA5B1
1.651 (1.216 to 2.241)
0.001
1.477 (1.098 to 1.986)
0.010
Molecular prognostic model
<0.001
<0.001
0.001
0.006
Medium-risk vs. ≤ low-risk
1.830 (1.215 to 2.758)
0.004
1.625 (1.111 to 2.378)
0.012
1.577 (1.036 to 2.402)
0.034
1.493 (1.010 to 2.208)
0.045
High-risk vs. ≤ low-risk
2.914 (1.828 to 4.680)
<0.001
2.457 (1.580 to 3.823)
<0.001
2.539 (1.556 to 4.141)
<0.001
2.122 (1.338 to 3.367)
0.001
Note. Multivariate analysis, Cox proportional hazards regression model. Variables were adopted for their prognostic significance by univariate analysis.
