Dunaliella salina Attenuates Diabetic Neuropathy Induced by STZ in Rats: Involvement of Thioredoxin

Figure 5

Brain section of normal control group showed the cerebellum showed normal histological features, a well-defined molecular (black arrow), granular (presence of numerous closely packed small cells in the granular layer) (red arrow), and Purkinje layers (large Purkinje cells) (yellow arrow) (a), with normal structure of neuronal cells of the frontal cortex (green arrow) (b). Brain section of the (STZ) control group showed the cerebellum edematous molecular (black arrow), disorganized and thin granular (presence of numerous closely packed small cells in the granular layer) (red arrow), and Purkinje layers showing moderate loss of Purkinje cells (yellow arrow) (c), neuronal cells of the frontal cortex showing perineuronal edema (blue arrow), showing widespread edema (blackhead arrow) and proliferation of oligodendroglia “satellitosis” (white arrow) (d). Brain section of the glimepiride group showed the cerebellum molecular layer (black arrow), granular (presence of numerous closely packed small cells in the granular layer) (red arrow), and loss of some Purkinje cells (yellow arrow) (e), with normal neuronal cells of the frontal cortex (green arrow), perineuronal edema (blue arrow), and few oligodendroglia “satellitosis” (white arrow) (f). Brain section of the D. Salina powder 100 mg/kg group showed the cerebellum molecular (black arrow), granular (presence of numerous closely packed small cells in the granular layer) (red arrow), and widespread necrosis and moderate loss of Purkinje cells (yellow arrow) (g), almost normal neuronal cells of the frontal cortex (green arrow), showing perineuronal edema (blue arrow), proliferation of oligodendroglia “satellitosis” (white arrow) (h). Brain section of the D. Salina powder 200 mg/kg group showed the cerebellum almost normal molecular layer (black arrow), granular (presence of numerous closely packed small cells in the granular layer) (red arrow), and Purkinje cells (yellow arrow) (i), with almost normal neuronal cells of the frontal cortex (green arrow) and perineuronal edema (blue arrow) (j). (H & E stain, x400).

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