A 5-Gene Signature Is Closely Related to Tumor Immune Microenvironment and Predicts the Prognosis of Patients with Non-Small Cell Lung Cancer

Table 3

The univariate and multivariate Cox proportional hazard regression analyses between the 5-gene signature and other clinical factors of NSCLC patients.

Variables	Univariable analysis				Multivariable analysis
	HR	Lower	Higher		HR	Lower	Higher
5-gene signature (high vs. low)	3.93	2.17	7.1	0	5.18	2.6995	9.945	<0.001
Lymphovascular invasion (yes vs. no)	1.37	0.58	3.26	0.476	1.03	0.4226	2.514	0.947
Pleural invasion (yes vs. no)	1.15	0.6	2.2	0.679	1.38	0.6977	2.745	0.352
Chemotherapy (yes vs. no)	1.1	0.59	2.05	0.76	0.94	0.4066	2.168	0.883
Radiation (yes vs. no)	1.26	0.56	2.84	0.579	1.42	0.4903	4.107	0.519