14-CpG-Based Signature Improves the Prognosis Prediction of Hepatocellular Carcinoma Patients

Table 3

Basic characteristics of the 14 methylation markers and their coefficients weighted by multivariable Cox regression analysis (development dataset, N = 263).

Markers	Ref gene	Coefficients	Hazard ratio	95% CI	value
cg00504595	TNFRSF19	4.10	60.34	6.51–559.57	<0.000
cg04711324	RIT2	3.79	44.11	5.49–354.79	<0.000
cg06226384	CACNG5	2.83	16.88	2.35–121.29	0.005
cg07014174	KRTAP11-1	1.76	5.83	0.95–35.72	0.056
cg08668790	ZNF154	0.54	1.72	0.66–4.51	0.269
cg15747595	TSPYL5	1.08	2.95	0.27–32.73	0.378
cg16673198	CPNE4	−2.29	0.10	0.03–0.39	<0.000
cg18343292	MS4A7	−2.76	0.06	0.01–0.52	0.01
cg18536148	TBX4	0.59	1.80	0.47–6.89	0.388
cg21578906	SLC5A4	−1.93	0.15	0.03–0.65	0.012
cg23163573	SULT1C2	−1.78	0.17	0.02–1.29	0.086
cg24432073	CDKL2	1.92	6.85	1.57–29.79	0.01
cg24898863	S100A8	−2.28	0.10	0.003–2.87	0.181
cg26059632	SPRR2A	−0.60	0.55	0.07–4.28	0.567