Evaluation of Microcirculation in Optic Nerve Head Using Laser Speckle Flowgraphy in Active Thyroid Eye Disease

Table 1

Clinical characteristics and MBR in active thyroid eye disease group.

	Mild		Moderate to severe		Sight-threatening		value
No. of eyes, (%)	12		31		17
Age, mean (SD)	42.6	(10.0)	46.8	(12.7)	57.3	(11.2)	0.003
Gender, male (%)	2	(16.7)	15	(48.4)	4	(23.5)	0.074
Smoking, (%)	1	(0.1)	3	(0.1)	1	(0.1)	>0.999
History of high-dose intravenous steroid treatment, (%)	3	(25.0)	15	(48.4)	12	(70.6)	0.052
History of orbital decompression, eyes (%)	0	(0)	1	(3.2)	5	(29.4)	0.014
Systemic findings
SBP, mmHg, mean (SD)	98.5	(34.6)	140.4	(24.4)	122.3	(22.8)	0.002
DBP, mmHg, mean (SD)	86.2	(20.9)	82.3	(15.1)	74.0	(10.5)	0.503
MAP, mmHg, mean (SD)	85.5	(10.3)	100.7	(15.3)	90.1	(12.3)	0.119
MOPP, mmHg, mean (SD)	59.8	(34.2)	49.9	(10.5)	40.4	(8.7)	0.364
HR, bpm, mean (SD)	68.8	(14.6)	69.8	(9.2)	62.5	(11.6)	0.890
Ocular findings
BCVA (logMAR), mean (SD)	0.08	(0.1)	0.08	(0.2)	0.29	(0.3)	0.005
IOP (primary gaze), mean (SD), mmHg	15.3	(3.8)	18.8	(4.9)	19.5	(3.4)	0.031
IOP (upward gaze), mean (SD), mmHg	19.4	(4.0)	22.7	(5.2)	25.7	(4.9)	0.033
MBR, mean (SD)
MBR-overall	28.5	(2.7)	23.6	(3.2)	20.2	(4.3)	<0.001^†
MBR-vessel	57.1	(8.0)	47.0	(6.9)	39.3	(6.9)	<0.001^†
MBR-tissue	16.9	(3.1)	14.4	(2.9)	12.0	(2.7)	<0.001^†

, ^†. BCVA: best-corrected visual acuity; bpm: beats per minutes; DBP: diastolic blood pressure; HR: heart rate; logMAR: logarithm of the minimum angle of resolution; IOP: intraocular pressure; MAP: mean arterial pressure; MBR: mean blur rate; mmHg: millimeter of mercury; MOPP: mean ocular perfusion pressure: SBP: systolic blood pressure; SD: standard deviation.