Glutathione Upregulates the Expression of K_ATP Channels and Vasorelaxation Responses and Inhibits mPTP Opening and Oxidative Stress in the Heart Mitochondria of Old Rats

Table 2

Markers of oxidative stress in heart mitochondria and levels of total, oxidized, and reduced glutathione in heart tissue.

	Adult	Old
^•O2^- (nmol/min/mg protein)			^,#
H2O2 (pmol/mg protein)			^#
MDA (nmol/mg protein)			^#
DC (ng/mg protein)			^#
Total GSH (nmol/mg tissue)			1394.33 ± 73.21^,#
GSSG (nmol/mg tissue)
GSH (nmol/mg tissue)			^,#

Note: ^•O₂^-: superoxide; MDA: malondialdehyde; DC: diene conjugates; total GSH: total glutathione; GSSG: oxidized glutathione; GSH: reduced glutathione; data are represented as . In experiments, to determine markers of oxidative stress for all groups of animals, there were . Glutathione levels were measured in adult and old glutathione-treated rats () and old rats (). versus adult; ^# versus old.