Research Article

Computational Modeling and Evaluation of Potential mRNA and Peptide-Based Vaccine against Marburg Virus (MARV) to Provide Immune Protection against Hemorrhagic Fever

Table 3

HTL epitopes are presented with corresponding binding affinity and physiochemical properties.

ProteinsStart-endPeptidePercentile rankAntigenicityIFN epitopeAllergenicitySolubilityToxicity

Envelope glycoprotein425-439AQHLVYFRRKRSILW1.31.06+0.231.04-1.03

VP30178-192NRELLLLMARKMLPN1.80.47+0.221.77-1.22
123-137TLENLGHILSYLHRS2.10.47+0.31.34-1.27

VP24150-164SEWLLLEVTSAIHIS0.60.93+0.270.86-1.68

Antigenicity , IFN-gamma-inducing capability, nonallergenic threshold , solubility , and nontoxicity score of <0.