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HIV as a Comorbidity: Are We There Yet?

Call for Papers

Human immunodeficiency virus (HIV) infection was once viewed as a fatal disease. Now, however, many HIV-infected individuals taking combination antiretroviral (cART) therapy are living with HIV for decades. It is estimated that by the year 2015 over half of the people living with HIV will be over 50 years of age. Given that HIV has become a more manageable chronic disease, consideration of HIV infection as a comorbid condition may be warranted.

In normal aging, decline of immune system functioning is believed to contribute to increased age-related diseases that include nervous system disorders, diabetes, and cancer. In this context, HIV infection is believed to increase the aging process by at least 10 years. Thus, as treatments for HIV improve survival and quality of live and the population of individuals living with HIV continues to grow and to age, the scenario in which an HIV+ individual is diagnosed with other diseases that share common pathologies with HIV is expected. Given that HIV is in many cases a chronic, manageable disease, treatment strategies for diseases that are more difficult to treat than HIV may become a greater challenge. Whether HIV is considered as the index disease, partially causative, or instead a part of disease clustering, understanding the potential impacts that living with HIV and long term exposure to cART may have on coexisting diseases is important to effectively treat and manage the continuously evolving HIV patient population.

In parallel with increased life spans of HIV infected individuals, the prevalence of cognitive impairments in the HIV population continues to increase. When considering HIV as an underlying condition, numerous diseases that also affect the CNS are worsened by HIV infection. In this context, we invite investigators to contribute original research articles as well as review articles from clinical and basic research settings that increase our understanding of how HIV infection may complicate other diseases with a CNS component and other chronic diseases.

The objective of this special issue is to draw attention the concept of HIV as an underlying disease and the potential impact that HIV infection may have on the course of CNS dysfunction linked to diseases other than HIV. Potential topics include, but not limited to:

  • Cancer
  • Obesity
  • Diabetes
  • Hypertension
  • Cardiovascular diseases
  • Cerebrovascular diseases
  • Neurodegeneration
  • Psychiatric illnesses
  • Autoimmune diseases
  • Substance use disorders

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/infectious.diseases/hiv/ according to the following timetable:

Manuscript DueFriday, 4 July 2014
First Round of ReviewsFriday, 26 September 2014
Publication DateFriday, 21 November 2014

Lead Guest Editor

  • Dianne Langford, Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA, USA

Guest Editors

  • Beau Ances, Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
  • Robert Heaton, Department of Psychiatry, University of California San Diego, La Jolla, CA, USA