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Biomarkers of Brain Injury in the Critically Ill Patients

Call for Papers

Although neurological examinations remain the cornerstone of neurological assessments, using them as the sole instrument to assess brain function and especially secondary brain injury is severely hampered at the intensive care. This is due to several issues like the use of sedatives, the severity of the acute brain damage making neurological examinations to screen for additional secondary brain injury less sensitive, and the existence of co-occurring organ failure influencing the clinical picture. Prognostication is difficult during this acute phase on the intensive care unit except in the most obvious cases. With the arrival of computed tomography and MRI to the diagnostic armamentarium, we entered an era where a more accurate assessment of the initial and subsequent brain injury became more feasible. However, neuroimaging techniques also have their limitations in practical use and in prognostication. Today, we experience yet another era with a fast moving field of science of biomarkers of bodily fluids. As clinical examinations are hampered by many issues in especially the critically ill patients, accurate biochemical biomarkers reflecting (primary or secondary) brain damage could have a profound impact on the daily clinical practice in these patients.

This special issue will be devoted to (neurochemical) biomarkers related to acute or subsequent (secondary) brain injury in the critically ill patients. We particularly take interest in papers reporting about biomarkers in human samples with diagnostic or prognostic potential. Potential topics include, but are not limited to:

  • Traumatic brain injury
  • Encephalopathies (sepsis, etc.)
  • Subarachnoid hemorrhage
  • Ischemic strokes
  • Cardiac arrest
  • Epilepsy
  • Spinal cord injury

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/critical.care/bbi/ according to the following timetable:

Manuscript DueFriday, 27 December 2013
First Round of ReviewsFriday, 21 March 2014
Publication DateFriday, 15 May 2014

Lead Guest Editor

  • Wilson F. Abdo, Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Guest Editors

  • Fabio Silvio Taccone, Department of Intensive Care, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
  • Stefania Mondello, Department of Neurosciences, University of Messina, Messina, Italy
  • Luciana Mascia, Department of Anesthesiology and Intensive Care, University of Turin, Turin, Italy