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Redox Signaling in Degenerative Diseases: From Molecular Mechanisms to Health Implications

Call for Papers

Maintenance of normal intracellular redox status plays an important role in regulating many physiological processes. The cellular oxidation and reduction environment is influenced by the production and removal of reactive oxygen species (ROS). Unbalanced levels of ROS are a common characteristic of many acute and chronic degenerative diseases such as cancer, cardiovascular diseases, type II diabetes, acute liver, renal failure, and neurodegenerative disorders including Parkinson’s and Alzheimer’s diseases and stroke. On the other hand, in the last years it has been shown that ROS are not only detrimental to cells but at physiological level regulate a myriad of cellular processes including transcription regulation and cell signaling. Several reports support the hypothesis that cellular ROS levels could function as “second messengers.” The second-messenger properties of ROS are believed to activate signaling pathways by regulating kinases, phosphatases, transcription factors, or ion channels to coordinate the final response of the cell. Understanding the cross talk between signaling, ROS, and cell homeostasis is fundamental for understanding redox biology and disease pathogenesis.

Full length original research articles as well as review articles that report the mechanisms behind redox imbalance leading to signaling alteration and their involvement in the onset of degenerative diseases are particularly welcome. Moreover, papers dealing with the therapeutic strategies to restore the redox balance and the signaling pathways to slow or halt these diseases will also be considered. Potential topics include, but are not limited to:

  • Role of ROS in molecular signaling
  • Redox signaling in heart failure
  • Redox regulation of stem cell signaling
  • Redox regulation of angiogenesis
  • Redox signaling in neurodegenerative disease
  • Redox signaling in inflammation
  • Redox signaling in aging
  • Redox signaling modulation to counteract degenerative diseases

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/biochemistry/rsdd/ according to the following timetable:

Manuscript DueFriday, 15 November 2013
First Round of ReviewsFriday, 7 February 2014
Publication DateFriday, 4 April 2014

Lead Guest Editor

  • Cristina Angeloni, Department of Life Quality Studies, Alma Mater Studiorum University of Bologna, Italy

Guest Editors

  • Tullia Maraldi, Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
  • David Vauzour, Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK