Corneal cross-linking, a technique employing UV-A illumination and a photomediator to induce corneal rigidity, is a widely recognized procedure for the stabilization or even possibly reversal of corneal ectasia progression in patients with keratoconus and post-LASIK ectasia. A rapidly growing number of clinical reports suggest a consistent stabilizing effect of cross-linking along with a variable improvement in corneal shape and visual function in some patients. In the past ten years there has been a continuous effort into understanding, ensuring safety and efficacy, further expanding its applications, and exploring modifications aiming to optimize the technique. Recent advances in corneal cross-linking include applications for infections treatment that do not respond to topical medications; accelerated, high-fluence applications; prophylactic application in refractive surgery; modified beam profiles for selective treatments; fully customized induction of refractive changes in nonectatic eyes.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the clinical application, underlying mechanism, the development of strategies, and the evaluation of outcomes of the technique. We are particularly interested in articles describing novel modalities for corneal clinical cross-linking and measuring outcomes from treatment, advances in application and diagnostics, new insights into further applications, and current concepts of the treatment. Potential topics include, but are not limited to:

• Applications of high-fluence, accelerated cross-linking
• Advances in understanding and complications assessment
• Latest technologies for corneal imaging and mapping, to include Scheimpflug, Placido, point-source topography and anterior segment OCT
• Corneal epithelial remodeling responses after refractive and CXL surgery
• Customized applications, clinical evaluation, and measuring outcomes
• Combined applications of cross-linking with refractive surgery

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http:///www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/ophthalmology/cci/ according to the following timetable: