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Ileal Pouch Complications and Failures: Causes, Diagnoses, and Treatments

Call for Papers

The introduction of restorative proctocolectomy, by means of an ileal pouch-anal anastomosis construction, has revolutionized the treatment and has offered a marked improvement in bowel function and quality of life of patients with ulcerative colitis or familial adenomatous polyposis. Restorative proctocolectomy is, though, plagued by a significant morbidity related to a multitude of complications, which may require medical or interventional treatment. Pouchitis is the most common complication following ileal pouch-anal anastomosis in patients with ulcerative colitis, and despite the recognized treatment modalities for the management of this chronic idiopathic inflammatory entity, its relapse rate remains disturbingly high. The initial misdiagnosis of ulcerative colitis instead of Crohn’s disease may further contribute to various complications leading to pouch failure or dysfunction. Surgical complications related to pelvic sepsis and mechanical pouch malfunction constitute the prime reasons for a revisional procedure. Even though conservative measures and expectant management may alleviate some of those problems, salvage reoperations or other types of remedial procedures have been devised and reported since proctocolectomy was incorporated in the routine surgical practice of inflammatory bowel diseases.

The main focus of this special issue will be on ileal pouch complications and failures, aiming at achieving better understanding of the underlying patients and treatment-related parameters, which contribute to these adverse events, as well as defining therapeutic strategies for improved outcomes. We particularly take an interest in original research and review articles discussing relevant information on epidemiology, clinical features, risk factors, diagnostic testing, differential diagnosis and treatment of pouchitis, and other postpouch incidences commonly encountered in the gastroenterological practice. Manuscripts focusing on the wide array of interventional options for salvaging pouches after a septic or a mechanical complication will also be at the center of attention at this issue. Potential topics include, but are not limited to:

  • Clinically relevant mechanisms of pouchitis pathogenesis
  • Advances in diagnostic means of pouchitis, including the role of predictive biomarkers
  • Contemporary management algorithms for pouchitis and other related pouch pathologies
  • The role of imaging and endoscopic modalities in pouch complications and failures
  • Technical details of both innovative and conventional interventional options for managing pouch complications
  • Variables of clinical significance affecting the outcome of pouch salvage procedures
  • Future directions and clinical trials

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/gastroenterology/ileal/ according to the following timetable:

Manuscript DueFriday, 14 February 2014
First Round of ReviewsFriday, 9 May 2014
Publication DateFriday, 4 July 2014

Lead Guest Editor

  • George E. Theodoropoulos, First Department of Propaedeutic Surgery of Athens Medical School, Hippocration Hospital of Athens, Athens, Greece

Guest Editors