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Hemoglobinopathies in Different Countries

Call for Papers

Hemoglobinopathy (both structural and thalassemia) is a heterogeneous group of inherited diseases more common in the world and one of the major public health problems. The geographical distribution is related to two factors: (a) the origin and selective advantage of mutations in malaria regions and (b) the divergence of human populations. Each ethnic group has its own set of alleles although this is changing as a result of migration and globalization.

In this respect there are hemoglobin variant and mutations in countries where they had never been described before. An example of this is the Hb S which in its most severe form, sickle-cell anemia, has been recognized as a public health priority. Given that these countries adopt the recommendations set by the African Union in 2005 (Assembly of the African Union, Fifth Ordinary Session, 4-5 July, 2005, Sirte, Libya), UNESCO (33rd General Conference session, Comission II, 12 October, 2006, Paris, France), and WHO (117 Session-EB117/34 26 May, 2006). All together suggested the need to create specific sickle cell centers where we can perform neonatal screening and diagnosis, collect information, and provide education and both carriers and patients clinical care.

All these efforts are helping to discover new mechanisms to understand how the same genotype may have different phenotypes and clinical manifestations.

On the other hand the current status of genetic variation of hemoglobinopathies in different countries can help to understand the evolution of these pathologies as they are finding new gene combinations helping to provide appropriate genetic counseling.

We invite authors to submit original research and review articles that will show the current distribution and genetic variation of these conditions in different countries in order to develop a new genetic map. Potential topics include, but are not limited to:

  • Molecular diagnosis of hemoglobinopathies
  • Frequency and genetic variation in hemoglobinopathies
  • New markers associated with increased Hb
  • Methods of diagnosis and treatment of iron overload

Before submission, authors should carefully read over the journal’s Authors Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/hematology/hemog/ according to the following timetable:

Manuscript DueFriday, 21 March 2014
First Round of ReviewsFriday, 13 June 2014
Publication DateFriday, 8 August 2014

Lead Guest Editor

  • Paloma Ropero, Departamento de Hematología, Hospital Clinico San Carlos de Madrid,Madrid, Spain

Guest Editors

  • Maria Domenica Cappellini, Department of Medicine and Medical Specialties, University of Milan, Milan, Italy
  • Ana Maria Villegas, Departamento de Hematología, Hospital Clinico San Carlos de Madrid, Madrid, Spain
  • Henri Wajcman, Inserm, Paris, France
  • Holger Cario, Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany