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New Insights in Genomics of Chronic Lymphoid Leukemia

Call for Papers

Chronic lymphoid leukemia (CLL) is characterized by the presence of a genetic heterogeneity that is becoming apparent through studies of chromosomal alterations, the immunoglobulin heavy chain gene, epigenomic and miRNA deregulation, and genetic lesions identified by whole genome sequencing. Furthermore, a strong relationship exists between specific genetic aberrations and the clinical course of CLL, and emerging evidence implies microRNAs and methylation alterations in the pathogenesis of CLL. Recent advances in the biology of CLL have led to the development of new treatments based on B-cell receptor signaling pathways. Thus, future research in these fields should bring further insights into mechanisms of the origin and development of the disease.

We invite investigators to contribute original research articles and review articles that will stimulate the continuing efforts to understand the molecular pathology of CLL and the development of strategies to treat this condition as well as the evaluation of outcomes.

We are particularly interested in articles describing the advances in genomics of CLL and its translation in the clinical characterization of this disease and the results of treatment clinical trials. Potential topics include, but are not limited to:

  • Advances in cytogenetic abnormalities and somatic mutations in CLL
  • Advances in the knowledge of mutations of key tumor suppressor genes in CLL
  • Advances in genes recurrently mutated in CLL by next-generation sequencing
  • Epigenetic modifications in CLL and its potential role as therapeutic target
  • Recent advances in CLL drug delivery and clinical trials

Before submission, authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/hematology/genol/ according to the following timetable:

Manuscript DueFriday, 28 March 2014
First Round of ReviewsFriday, 20 June 2014
Publication DateFriday, 15 August 2014

Lead Guest Editor

  • José Ángel Hernández Rivas, Department of Hematology, Hospital Universitario Infanta Leonor, Universidad Complutense de Madrid, 28031 Madrid, Spain

Guest Editors

  • Paola Dal Cin, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School,Harvard University, Boston, MA 02115, USA
  • Ana-Eugenia Rodríguez-Vicente, Centro de Investigación del Cáncer, Universidad de Salamanca (CSIC), 37007 Salamanca, Spain