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Vitreous Substitutes: From Tamponade Effect to Intraocular Inflammation

Call for Papers

Vitreous substitutes have been developed as a postoperative tool for the surgical treatment of complicated vitreoretinal diseases. Although the tolerance for this group of substances is generally good, the introduction of new compounds over the past few years has been associated with relatively high complication rates, especially emulsification and severe inflammatory reactions leading to poor functional prognosis. Successful long-term vitreous substitutes require the use of substrates that are able to guarantee a tamponade effect and to diffuse oxygen successfully while transporting nutrients uniformly around and through the material.

We invite investigators to contribute original research articles as well as review articles to this special issue. We are particularly interested in manuscripts that report the relevance of biocompatibility of vitreous substitutes and their tamponade effect in vitreoretinal diseases. Potential topics include, but are not limited to:

  • Vitreous substitutes and immunologic reaction
  • Emulsion of intraocular tamponades
  • Evaluation of the cytotoxicity, hemocompatibility, and mutagenicity of intraocular tamponade
  • Modulation of biocompatibility induced by the variation of temperature of non-Newtonian fluids
  • Rheology and inflammation of vitreous substitutes in static and dynamic conditions
  • Heavy silicone oil and intraocular inflammation
  • Light silicone oil and intraocular inflammation
  • Shear retinal stress of vitreous substitutes
  • Oxygen and nutrient diffusion
  • Growth factor transport through the vitreous substitutes
  • Inflammation induced by perfluorcarbon liquid: Intra- and postoperative use
  • Tamponade effect or filling effect: Changes of forces in myopic eyes
  • New biomaterials under development: Hydrogels, thermosetting gels
  • Treatment of intraocular inflammation induced by vitreous substitutes

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/ophthalmology/vs/ according to the following timetable:

Manuscript DueFriday, 24 January 2014
First Round of ReviewsFriday, 18 April 2014
Publication DateFriday, 13 June 2014

Lead Guest Editor

  • Mario R. Romano, Department of Ophthalmology, Istituto Clinico Humanitas, Rozzano, 20089 Milan, Italy

Guest Editors

  • Xun Xu, Department of Ophthalmology, Shanghai Jiaotong University, Shanghai, China
  • Kenneth K.W. Li, Department of Ophthalmology, United Christian Hospital, Hong Kong