Pharmacological Application of Antiradical Compound Properties

Call for Papers

The production of reactive oxygen species (ROS) is part of human metabolism and participates in various physiological mechanisms, such as cytochrome P450-mediated oxidations, regulation of smooth muscle tone, and killing microorganisms. However, when the rate of ROS production exceeds the rate of removal by cellular defenses, oxidative stress occurs, which can activate a variety of transcription factors and thus lead to the expression of a wide variety of genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules, and anti-inflammatory molecules.

In recent years, increasing evidence implicates ROS in a variety of diseases and pathophysiological events including inflammation, cancer, cardiovascular disease, Alzheimer's disease, Parkinson's disease, and acute respiratory distress syndrome. This involvement suggests that antioxidant molecules can be useful to treat different diseases. Biological research on antioxidants and free radicals has produced promising results regarding new therapeutic approaches.

Natural and synthetic antioxidants can exert their effect in different ways. Antioxidant action can be attributed to direct scavenging capacity, stimulating endogenous antioxidant and/or activating physiological response.

Antioxidant therapies have emerged as an alternative for treating and/or preventing chronic degenerative diseases including cancer, cardiovascular diseases, inflammation, and neurodegenerative diseases. Potential topics include, but are not limited to:

• Free-radical scavenging properties of natural compounds
• Antiradical properties of synthetic molecules
• Design of metal chelating agents
• Biotechnology in antiradical systems
• Antioxidants as a new therapeutic approach
• Antioxidants and their benefits to health
• Endogenous antioxidants
• Antioxidants, longevity, and aging

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/pharmacology/acp/ according to the following timetable:

Lead Guest Editor

• Alethéa Gatto Barschak, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite 245, 90050-170 Porto Alegre, RS, Brazil

Guest Editors

• Francieli Moro Stefanello, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, RS, Brazil
• Claiton Leonetti Lencina, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Pelotas, RS, Brazil
• Filippo De Simone, Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK
• Wilson João Cunico Filho, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Pelotas, RS, Brazil