With the escalation of obesity, diabetes, and hypertension in all ages of the population including children, the incidence of cardiometabolic disease is on the rise, especially complications affecting vital organs like the heart and kidneys. Cardiometabolic complications are multifactorial diseases, and a wide variety of different pathophysiological factors are involved. Although the exact natures of these factors are not completely understood, it is widely accepted that genetic, habitual, environmental, and other epigenetic factors play a significant role.

In the past decade, great accomplishments have been made in elucidating some of the multifaceted mechanisms associated with many cardiometabolic diseases. A converging body of evidence indicates that a common denominator of many cardiometabolic diseases is the elevated inflammatory/oxidative insults that generally arise from the persistent inflammatory and oxidative milieu that characterize obesity, diabetes, and hypertension. However, more intense research in this and other related areas is needed for a more comprehensive understanding of the pathophysiological profile of these diseases, and especially in situations where they are manifested in comorbid forms.

Therefore, this special issue will welcome research and review papers that address a broad range of mechanisms associated with cardiometabolic diseases and possible prognostic and therapeutic interventions. Potential topics include, but are not limited to:

• Role of inflammation and oxidative stress in cardiometabolic complications
• The contribution of genetic and epigenetic factors in metabolic syndrome and related diseases
• Novel mechanistic, diagnostic, and therapeutic approaches in cardiometabolic complications including cardiopathy, nephropathy, vasculopathy, and neuropathy

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: