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Molecular Aspects of Environmental Sensing in Bacteria

Call for Papers

Bacteria can sense and respond to the environment—finding food, avoiding poisons, and targeting cells to infect—through various and complex processes in order to coordinate the appropriate response. How bacteria sense and adapt to multiple stimuli represents an issue of great importance across a variety of scientific, medical, and engineering disciplines, considering the fact that a large part of these adaptive responses influence complex biological phenomena including biofilm formation, antibiotic resistance, and evasion of the host immune defences.

Many sensing strategies have been identified which contribute to the regulation of cellular pathways. These include redox and stress sensors, which may mediate the cellular response either by directly altering the transcriptional profile or by using selected second messengers, such as c-di-GMP and c-di-AMP.

Given the involvement of these bacterial sensing pathways in controlling bacterial decisions, the biochemical analysis of these systems represent a hot topic for many researchers, as shown by the rise in the scientific production in the last ten years. Moreover, molecular data on bacterial sensing systems has represented the starting point for possible biotechnological applications of specific biosensors. Exploring signalling systems requires a multidisciplinary and synergic approach involving microbiologists, molecular, and structural biologists and biochemists.

We invite investigators to present original research articles as well as review articles that will contribute to understanding the molecular details controlling a wide array of sensing and signalling strategies in bacteria, with particular (but not exclusive) emphasis on redox sensing and dinucleotide signalling. Novel outcomes on basic and methodological researches are welcome in order to highlight, with this special issue, new directions in the signalling mechanisms field. Potential topics include, but are not limited to:

  • New insights into redox and/or stress sensing
  • Novel examples of gas sensors
  • Biochemical data on nitric oxide-dependent signalling systems
  • Biochemistry of dinucleotide-dependent signalling pathway
  • Recent developments in c-di-GMP and c-di-AMP signalling research, including biosensors
  • Novel sensing strategies in adaptive response to environmental stress

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/ . Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/molecular.biology/maes/ according to the following timetable:

Manuscript DueFriday, 25 July 2014
First Round of ReviewsFriday, 17 October 2014
Publication DateFriday, 12 December 2014

Lead Guest Editor

  • Serena Rinaldo, Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy

Guest Editors

  • Francesca Cutruzzolà, Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy
  • Shimizu Toru, Research Center for Compact Chemical System, National Institute of Advanced Industrial Science and Technology (AIST), Tohoku, Japan