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Rheumatologic Diseases, Atherosclerosis, and Cholesterol Metabolism: Implications for the Pathogenesis and Therapy of Cardiovascular Disease

Call for Papers

Autoimmune rheumatic diseases (AIRDs) are associated with accelerated atherosclerosis and increased cardiovascular risk not fully explained by traditional risk factors. In these conditions inflammatory and autoimmune mechanisms have been found to contribute significantly to atherosclerosis and the role of “classic” dyslipidemia has got less attention. Moreover, the link between lipid metabolism and atherosclerosis in AIRDs is more complex than that of general population, as emerging data are pointing to the role of lipoprotein dysfunction, rather than or beyond its serum levels, in favoring foam cell formation.

At present, experimental studies suggest a close relationship between cholesterol metabolism and inflammation/autoimmune mechanisms. Thus, there seems to be a need for a new approach in studying the premature cardiovascular disease in AIRDs, considering this relationship.

We invite investigators to contribute original research and review articles on pathogenesis of atherosclerosis and possible therapeutic perspectives in AIRDs.

Potential topics include, but are not limited to:

  • Lipoprotein dysfunction in AIRDs
  • Inflammatory/autoimmune proatherogenic mechanisms in AIRDs
  • Relationship between cell cholesterol homeostasis and inflammation/immune activation
  • Effects of cholesterol-lowering drugs on inflammation and immune function
  • Effects of disease modifying antirheumatic drugs on cholesterol metabolism and atherosclerosis
  • Cholesterol homeostasis and foam cell formation in synovitis
  • Future therapeutic targets
Manuscript DueFriday, 24 October 2014
First Round of ReviewsFriday, 16 January 2015
Publication DateFriday, 13 March 2015

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Guest Editors