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Agents Targeting Hypoxic and Nutrient-Deprived Tumor Microenvironment

Call for Papers

Because tumor cells generally grow rapidly, their demand for nutrition and oxygen often exceeds supply due to the unregulated growth. Cancer cells showed adaption to tolerate extreme conditions, such as those characterized by low nutrient and oxygen supply. Hypoxic and nutrient-deprived tumors are often resistant to conventional cancer therapies and correlate with advanced stages of malignancy. Therefore, it is important to develop agents targeting hypoxic and nutrient-deprived tumor microenvironment. Although a number of inhibitors with antiausterity activity have been isolated and developed, more efficient compounds or natural products targeting nutrient-deprived cancer cells are with great need to be isolated, structurally characterized, and evaluated as antiausterity anticancer agents.

We invite authors to contribute original research and review articles that will stimulate the exploration of natural bioactive targeting nutrient-deprived cancer cells by basic research, clinical practice, and clinical research. In this special issue, we particularly take an interest in manuscripts that evaluate and discuss the rationale, methods, preliminary mechanism, clinical practice guideline, or expert consensus for antiausterity related therapies.

Potential topics include, but are not limited to:

  • Recent advances of natural bioactives targeting hypoxic and nutrient-deprived cancer cells
  • The use of natural bioactive in antiausterity therapies
  • Ex vivo and in vivo studies related to the antiausterity therapies
  • SAR studies (structure/activity relationship) of antiausterity natural compounds
Manuscript DueFriday, 22 August 2014
First Round of ReviewsFriday, 14 November 2014
Publication DateFriday, 9 January 2015

Lead Guest Editor

  • Jian-Li Gao, Zhejiang Chinese Medical University, Hangzhou, China

Guest Editors