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Epigenetics and Disease: From Markers to Mechanisms

Call for Papers

Epigenetic alterations are thought to play an important role in the molecular aetiology of many diseases. Changes to DNA methylation, histone modifications, nucleosome positioning, micro-RNAs, long noncoding RNAs, or nuclear organisation have been implicated in diverse pathological states. These include cancer, metabolic diseases such as type 2 diabetes mellitus and obesity, viral and bacterial infection, and imprinting disorders.

Generating genomewide data is no longer a technical or financial barrier and in the past decade our ability to characterise epigenetic alterations in disease states has increased at a spectacular rate. Consequently, increasingly innovative bioinformatics solutions are required for analysis and integration of large datasets.

This special issue will focus on the epigenetic basis of disease. We invite investigators to contribute original research and review articles in the following.

Potential topics include, but are not limited to:

  • Genomewide epigenetic profiling
  • Advances in bioinformatics analysis of genomewide epigenetic data
  • Epigenetic biomarkers of diagnostic, prognostic, or predictive potential
  • Epigenetic alterations in disease including changes to DNA methylation, hydroxymethylation, non-CpG methylation, histone modifications and variants, nucleosome positioning, and nuclear organisation
  • Genetic drivers of epigenetic changes
  • Epimutations
  • The mechanistic basis of epigenetic gene regulation
Manuscript DueFriday, 21 November 2014
First Round of ReviewsFriday, 13 February 2015
Publication DateFriday, 10 April 2015

Lead Guest Editor

Guest Editors

  • Jason Wong, UNSW Australia, Sydney, Australia
  • Romain Barres, University of Copenhagen, Copenhagen, Denmark
  • Duncan Sproul, University of Edinburgh Western General Hospital, Edinburgh, UK