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Diabetic Nephropathy: Pathogenesis, Progression, Mechanisms, and Therapies

Call for Papers

Diabetic nephropathy is the number-one cause of end-stage renal disease (ESRD). Current treatment strategies involve blood glucose and blood pressure control that focused on the renin angiotensin system inhibitors. However, these approaches are modestly successful in delaying the progression of renal failure. Accordingly, understanding the molecular mechanisms that drive disease progression where renal dialysis and kidney transplant are the only treatment option could prevent the incidence of ESRD. New approaches that prevent the incidence of endothelial dysfunction and renal inflammation, the early signs of diabetic nephropathy, are also crucial to halt the disease progression. Recent advances in biology and medicine have introduced new technologies to study the genetics of renal injury and the mechanisms underlying their pathology. Knowledge and understanding of these conditions have led to the development of animal models, successful therapies, and novel tools to characterize these clinical conditions and provide better care to patients.

We invite investigators to contribute with original research papers as well as review papers that will stimulate the continuing efforts to understand the molecular pathology underlying renal failure, the development of strategies to treat these conditions, and the evaluation of outcomes. We are particularly interested in papers describing the new modalities for clinical characterization of diabetic nephropathy and measuring outcomes from treatment trials; advances in molecular genetics and molecular diagnostics; new insights into renal injury using animal models; current concepts in the treatment of diabetic nephropathy using anti-inflammatory molecules, SiRNA, stem cells, and viral and nonviral gene therapy strategies. Potential topics include, but not limited to:

  • Recent developments in diabetic nephropathy
  • Advances in genetics of renal injury
  • Latest technologies for clinical evaluation and measuring outcomes of renal failure
  • Role of inflammation in renal injury
  • Mechanisms of the incidence and progression of ESRD
  • New animal models to study the incidence and progression of renal injury
  • Recent advances in treatment of diabetic renal injury and halting the disease progression to ESRD

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http:///www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/physiology/diaben/ according to the following timetable:

Manuscript DueFriday, 14 February 2014
First Round of ReviewsFriday, 9 May 2014
Publication DateFriday, 4 July 2014

Lead Guest Editor

  • Ahmed A. Elmarakby, Department of Oral Biology and Pharmacology, Georgia Regents University, 1120 15th Street, CL2126, Augusta, GA 30912, USA

Guest Editors

  • Jan M. Williams, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, USA
  • Mohammed A. Nayeem, Department of Physiology and Pharmacology, West Virginia University 1 Medical Center Drive, P.O. Box 9229, Morgantown, WV 26506-9229m, USA