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Advance in Invasive Fungal Infection: Contributions of Pathology and Laboratory Medicine

Call for Papers

Several antifungals are currently available for management of invasive fungal infections (IFI), but this exacerbating infectious disease still presents difficulties, especially in the case of opportunistic infection occurring in individuals with seriously impaired defense mechanisms. Due to a lower prevalence of culture-proven cases of IFI, physicians may be forced to make a management decision on the basis of information obtained by other supplemental procedures, for instance, serum antigens or antibodies molecular detections, images, and so on. Lack of typical signs and/or symptoms is essential characteristics of the disease because most are opportunistic infections in patients with variously challenged immunity induced by diverse mechanisms. Therefore, supplemental procedures for diagnosis, such as indirect monitoring of pathophysiology of the infection, have become a more important and practical way for management of the disease.

This issue should make an impact on the contribution of laboratory examinations in monitoring dynamic change of pathophysiology in individuals with invasive fungal infection. Histopathological and cytological examination can also be accepted as an important procedure to identify causative fungi in tissue or primary clinical specimens, for instance, sputum, aspirated exudates, urine, and so forth.

Potential topics include, but are not limited to:

  • Induced immunocompromised conditions, mechanisms, prevalence, and relationship between IFI
  • Pathophysiology of invasive fungal infections, blood stream infection caused by Candida or other pathogenic yeasts, acute pulmonary invasive aspergillosis, chronic pulmonary aspergillosis, invasive Mucor infection, and other mold infections
  • Invasive yeast infection, especially those producing granulomatous inflammation in competent individuals, such as Cryptococcosis and marneffei penicilliosis
  • Virulence of fungi causing invasive disease, including specific molecules produced by fungi and surface structures relating to recognition.
  • Evaluation of serum antigen testing
  • Usefulness of molecular diagnosis
  • Histopathological or cytological examination, including special staining and in situ hybridization
  • When should a patient be treated based on clinical and laboratory findings
Manuscript DueFriday, 19 September 2014
First Round of ReviewsFriday, 12 December 2014
Publication DateFriday, 6 February 2015

Lead Guest Editor

Guest Editors

  • Mahmoud Ghannoum, Case Western Reserve University, Cleveland, USA
  • Ruoyu Li, Peking University First Hospital, Beijing, China