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Glycosaminoglycans and Derivatives for the Regulation of Healing Processes: From Synthesis to Biomaterial Application

Call for Papers

Glycosaminoglycans (GAGs) are prominent components of the extracellular matrix (ECM) and play multiple roles during tissue development and in regeneration processes. As a part of proteoglycans (PGs), GAGs occur both within the ECM and bound to the cell surfaces. They can interact with cytokines and chemokines and, thus, contribute to the regulation of the biological availability and activity of these factors. In this respect both the composition of the sugar backbone and the sulfation code of the GAG are major factors as they determine these interactions. Additionally, other pathways of influencing biological reactions are also discussed for the GAG, such as direct incorporation by cells.

Against this background, we invite investigators to submit original research articles as well as review articles that will contribute to the continuing efforts to improve the current understanding of the role of GAG in the biological processes of tissue formation and regeneration as well as the use of GAG in biomaterial applications. Potential topics include, but are not limited to:

  • Recent developments in the synthesis and characterization of ECM specific polysaccharides including biomimetic PG-analog, with a special focus on methods to produce highly defined functionalization patterns
  • Recent developments in biophysical methods to study GAG protein interactions
  • Sophisticated molecular modeling approaches for the analysis of GAG protein interactions, including screening methodologies for the prediction of biological activity profiles
  • Biomaterial applications of GAG for the regulation of healing processes
  • Role of GAG in mediating inflammatory processes
  • Role of GAG and GAG/cytokine and/or chemokine interactions in cellular processes related to tissue formation and regeneration
  • Molecular pathways triggered by GAG and GAG/cytokine interactions
  • Recent advances in animal models to analyze the potential of GAG-based biomaterial applications, including systemically compromised models

Before submission authors should carefully read over the journal's Author Guidelines which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/biomaterials/gheal/ according to the following timetable:

Manuscript DueFriday, 31 January 2014
First Round of ReviewsFriday, 25 April 2014
Publication DateFriday, 20 June 2014

Lead Guest Editor

  • Dieter Scharnweber, Max Bergmann Center of Biomaterials, Institute of Materials Science, Dresden University of Technology, Dresden, Germany

Guest Editors

  • Peter Dubruel, Faculteit WetenschappenVakgroep Organische Chemie Onderzoeksgroep Polymeerchemie (PBM), Universiteit Gent, Krijgslaan 281 (S4bis), 9000 Gent, Belgium
  • Daniel Huster, Institute for Medical Physics and Biophysics, Leipzig University, 04107 Leipzig, Germany
  • Bernd Stadlinger, Clinic of Cranio-Maxillofacial and Oral Surgery, University of Zurich, 8032 Zurich, Switzerland