Yeast Genetic and Metabolic Engineering in Biotechnology

Call for Papers

Diverse yeast species including conventional Saccharomyces cerevisiae and nonconventional Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Kluyveromyces lactis, and others are widely used in biotechnology for production of various metabolites and recombinant proteins. In some cases, yeasts are not ideal cell factories. There are problems hampering the production of metabolites and high yield of properly modified and active recombinant proteins. For example, activity of the heterologous proteins is often negatively affected by undesired host-specific modifications (e.g., hypermannosylation) or absence of proper modifications specific for the given protein in the original organism. One of the powerful approaches to improve biotechnological potential of yeasts is their genetic modification by random mutagenesis. Availability of various omics and bioinformatic tools in the postgenomic era promotes the development of more efficient strategy —a rationale genetic engineering of yeasts based on systems biology approach.

We invite investigators to contribute original research articles and reviews on genetic engineering of various yeasts as hosts for production of heterologous proteins or metabolites having diverse applications in fundamental research or applied sciences. Potential topics include, but are not limited to:

• Identification of problems hampering production of heterologous proteins and metabolites
• Methods and approaches for genetic manipulation of yeast cells
• Assembly of artificial biochemical pathways
• Engineering of simple genomes in yeasts
• Yeast synthetic biology
• Yeasts in industrial biotechnology
• Yeasts for production of pharmaceutical proteins
• Yeasts as biocatalysts for production of metabolites
• Genetically modified yeasts in food industry

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/biotechnology/yg/ according to the following timetable:

Lead Guest Editor

• Gotthard Kunze, Department of Molecular Cell Biology, Leibniz Institute for Plant Genetics and Crop Plant Research, Gatersleben 06466, Germany

Guest Editors

• Dmitry Karpov, Laboratory of Chromatin Structure and Functions, Engelhardt Institute of Molecular Biology RAS, Moscow 119991, Russia
• Alok K. Mondal, CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, India
• Kostyantyn Dmytruk, Department of Molecular Genetics and Biotechnology, Institute for Cell Biology, NAS of Ukraine, Lviv 79005, Ukraine