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Tools for Early Diagnosis of AKI: Combining Old and New Strategies

Call for Papers

Acute kidney injury (AKI) remains a major cause of increased morbidity and mortality in critically ill patients. Hence, early diagnosis of AKI is a logical target in order to decrease the negative impact on outcome. It is well known that both serum creatinine and urine output, currently the two variables used to diagnose AKI, are late markers of kidney dysfunction. Besides the long used urine biochemistry and microscopy, many other tools have emerged in recent years to help in the early AKI diagnosis. Alternative filtration markers, creatinine, iothalamate, iohexol, and EDTA, have a limited application in the clinical practice. More accurate and rapid measures of GFR as well as other laboratory measurements (tubular injury biomarkers measured in blood and urine) and perfusion image techniques (ultrasound Doppler and dynamic contrast-enhanced magnetic resonance imaging) are yet to be validated in clinical use, and the costs and convenience are under consideration.

We invite authors to submit original research as well as review articles focusing on different methods to estimate kidney function, especially those that may reliably reflect fast declines in the glomerular filtration rate that commonly occurs in critical illness. Potential topics include, but are not limited to:

  • Studies using urine output and serum creatinine-based approaches in diagnosing AKI
  • Studies using alternative filtration markers, such as creatinine, iothalamate, iohexol, and EDTA in diagnosing AKI
  • Studies focusing on urinary microscopy, biochemistry, and biomarker as parameters for AKI
  • Studies focusing on calculated creatinine clearance in AKI settings to predict clinical outcomes
  • Clinical application of new biomarkers in AKI

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/critical.care/edaki/ according to the following timetable:

Manuscript DueFriday, 7 February 2014
First Round of ReviewsFriday, 2 May 2014
Publication DateFriday, 27 June 2014

Lead Guest Editor

  • Etienne Macedo, Medical School, University of São Paulo, Cerqueira César, SP, Brazil

Guest Editors