Radiobiology of Stereotactic Radiosurgery

Call for Papers

Stereotactic radiosurgery is a treatment technique that uses a single high dose of radiation to elicit a desired radiobiological effect in a defined target volume. This concept, in radiobiological perceptions, generates effects that are different from those of fractionated irradiation. Radiosurgery represents the ultimate in hypofractionation, in that the entire dose is given in a single fraction. The impact of ionizing radiation varies according to the nature of the tissue. Single large fractions produce substantially greater damage in slowly proliferating or "late-responding" tissues, whereas fractionated radiotherapy decreases the effect on such late-responding tissues. It has been questioned that the basic radiobiological principles, which have been learned over 70 years of experience with conventional radiotherapy, may be of some help for the understanding of radiosurgery. The radiobiological concept of radiosurgery for benign and malignant lesions is starting to be understood, although still controversial with respect to homogeneity/heterogeneity within the target volume. Furthermore, a new trend to treat functional diseases with radiosurgery has emerged, where little radiobiological evidence exists, especially regarding the desired effect, which ranges from subnecrotic functional changes to necrotic lesions.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the radiobiological effects of radiosurgery. We are particularly interested in articles describing new radiobiological models for radiosurgery, the radiobiological effects of radiosurgery in radioresistant lesions, and all radiobiological approaches with regard to functional treatments. Potential topics include, but are not limited to:

• Methods to create a radiobiological model
• Existing models for radiosurgery
• Radiobiological evidence of radiosurgery for radioresistant lesion
• Radiobiology for malignant and benign lesions
• Radiobiology for functional disease
• Future of radiobiology

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/oncology/rsr/ according to the following timetable:

Lead Guest Editor

• Mark De Ridder, Department of Radiation Oncology, Vrije Universiteit Brussel, Elsene, Belgium

Guest Editors

• Marc Levivier, Neurosurgery Department, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
• Thierry Gevaert, Department of Radiation Oncology, Vrije Universiteit Brussel, Elsene, Belgium