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Molecular and Cellular Mechanisms in Skeletal Muscle Unloading and Reloading

Call for Papers

Muscle inactivity (unloading and disuse) may be induced by various causes including microgravity (space flight), simulated microgravity in humans and animals (head-down tilt bed rest, unilateral limb unloading, “dry” water head-out immersion, cast immobilization, tenotomy, and hindlimb suspension), and central or peripheral impairment of innervation. No doubt that all of these conditions have clinical or other practical importance (e.g., in astronautics). Skeletal muscles respond to disuse with various ways of remodeling, including fiber atrophy, decline in stiffness and contractile properties, increased fatigue, impairment of the energy metabolism, and changes in contractile protein expression patterns.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular and cellular mechanisms, underlying muscle atrophy, and other consequences of muscle unloading. We are particularly interested in articles describing molecular mechanisms involved in the regrowth of the atrophic muscle and application of antiatrophy countermeasures and rehabilitation means. We invite authors working with the different models of muscle inactivity and recovery and focusing on the molecular nature of the disuse. Potential topics include, but are not limited to:

  • Molecular mechanisms of muscle contraction in disuse conditions, cellular stiffness and atonia, and myofibrillar and myofiber contractile properties in unloaded and reloaded muscle
  • Calcium sensitivity and ECC and ion channels in unloaded and reloaded muscle
  • Anabolic and catabolic signaling pathways and posttranslational modifications in muscle unloading and reloading
  • Energy metabolism and energy-coupled signaling pathways under conditions of disuse and regrowth
  • Control of gene expression and epigenomics in unloaded and reloaded muscle
  • Alterations in contractile protein fiber phenotypes
  • Sarcomeric and nonsarcomeric cytoskeletal proteins in unloaded and reloading muscle
  • Molecular mechanosensors and mechanotransduction during unloading and reloading
  • Molecular mechanisms of the neural control of skeletal muscle during unloading and reloading
  • Myonuclei and satellite cells during unloading and reloading
  • Molecular mechanisms of countermeasure and rehabilitation means against muscle atrophy

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/physiology/skun/ according to the following timetable:

Manuscript DueFriday, 15 August 2014
First Round of ReviewsFriday, 7 November 2014
Publication DateFriday, 2 January 2015

Lead Guest Editor

  • Boris S. Shenkman, Laboratory of Myology, State Scientific Center of the Russian Federation Institute of Bio-medical Problems, Russian Academy of Sciences, Moscow, Russia

Guest Editors

  • Zhi-Bin Yu, Department of Aerospace Physiology, Fourth Military Medical University, Shaanxi, China
  • Yvonne Mounier, University of Sciences and Technologies-Lille1, Lille, France