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Modulation of Liver Immune Response

Call for Papers

Most liver diseases are affected by various kinds of immune responses. In addition to the pathogeneses of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC), those of viral hepatitis B (HBV) and viral hepatitis C (HCV) infections, nonalcoholic fatty liver diseases (NAFLD), and hepatocellular carcinoma (HCC) include the modification of immune responses. AIH and PBC are pathological conditions in which self-tolerance mechanisms are altered, leading to the attack of the body’s own tissues by autoreactive lymphocytes. On the other hand, the persistent infections of HBV and HCV cause the suppression of the innate and adaptive immune systems. The various mechanisms of immune suppression in HCV, HBV, and HCC were clarified to improve the treatment efficacy and the management of liver damage. The modifications of the immune responses in HBV infection are one of the most important issues that might be related to the control of HBV replication. The mechanisms of immune suppression of HCCs were studied to improve the treatment efficacy. Myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAM), and Tregs are attractive targets of immune-suppressive cells in the tumor microenvironment.

This special issue will welcome papers describing the state-of-the-art mechanisms of immune modulation and immune modulating therapy, current limitations, and future perspectives on modulation of the liver immune response.

We invite investigators to contribute original research papers, as well as reviews, on modulation of the liver immune responses. Potential topics include, but are not limited to:

  • The role of innate and adaptive immune response in AIH, PBC, and viral hepatitis
  • Immune evasion
  • The suppression of innate and adaptive immune responses in HBV and HCV persistent infection
  • The modification of immune responses that could contribute to the control of HBV and HCV replication
  • The contribution of immune responses causing liver damage in NAFLD
  • The mechanism of immune suppression in the HCC microenvironment
  • The development of immune therapy for various kinds of liver diseases

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/gastroenterology/mlire/ according to the following timetable:

Manuscript DueFriday, 25 October 2013
First Round of ReviewsFriday, 17 January 2014
Publication DateFriday, 14 March 2014

Lead Guest Editor

  • Yasuteru Kondo, The Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan

Guest Editors

  • Keigo Machida, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, LA, USA
  • Kazumoto Murata, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan
  • Yasuhito Tanaka, Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan