The treatment of large bone defect still remains a major clinical challenge worldwide. Bone tissue engineering (BTE) strategies have been developed and demonstrated great potential to address this ever-pressing clinical need. The success of BTE strategies requires the synergetic efforts from multidisciplinary research fields including stem cell, scaffold, and bioreactor. Furthermore, in order to ensure their clinical efficacy, it is essential to promote rapid vascularization for higher implant survival rate and to apply favorable mechanical stimulation for better bone tissue remodeling.

We invite investigators to submit original research and review articles to contribute to the fast-evolving research filed of BTE and the development of clinically effective BTE strategies. We are interested in the BTE research work in terms of stem cell, scaffold, and bioreactor, in particular cell migration, in vivo tracking of implanted cell, cellular and molecular pathways of osteogenesis, and micro-nanopatterning of scaffold. In addition, we feel interested in the advance of BTE enabling technologies, such as prevascularization strategies, the role of novel mechanotransduction, and the mechanism study about the bone tissue remodeling after BTE treatment. Potential topics include, but are not limited to:

• Stem cells research for BTE application
• Biomaterial research and scaffold development for BTE application
• Bioreactor design and development for BTE application
• Recent advances in prevascularization strategies
• Role of mechanotransduction in bone tissue remodeling and its application in BTE research

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/tissue.engineering/bten/ according to the following timetable: