Insulin Blocks Glutamate-Induced Neurotoxicity in Differentiated SH-SY5Y Neuronal Cells

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Treatment</td><td align="center">Apoptotic cells (% of total)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Control</td><td align="center">6.50 ± 2.50</td></tr><tr><td align="left">Glutamate (20 mM)</td><td align="center">35.33 ± 2.91**</td></tr><tr><td align="left">Glutamate + insulin (0.1 <i>μ</i>M )</td><td align="center">11.67 ± 3.71<sup>##</sup></td></tr><tr><td align="left">Glutamate + insulin (1 <i>μ</i>M)</td><td align="center">13.22 ± 2.79<sup>##</sup></td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>Values are expressed as mean ± SEM of three tests in triplicate. Statistical analysis was done by using one-way ANOVA followed by Tukey’s multiple comparison test. **<i>P</i> &lt; 0.01 compared to control group. <sup>##</sup><i>P</i> &lt; 0.01 compared to glutamate group.<br/></td></tr></table>

Percentage of apoptotic cells in differentiated SH-SY5Y cells after treatment.

Behavioural Neurology

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Table 3

Table 3: Insulin Blocks Glutamate-Induced Neurotoxicity in Differentiated SH-SY5Y Neuronal Cells 