Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats
Table 2
Effect of simvastatin on AlCl3-induced biochemical changes on frontal cortex.
Treatment
MDA (nmol/mg of protein)
Nitrite (nmol/mg of protein)
Reduced glutathione (μmol/mg of protein)
Catalase (μmol of H2O2 decomposed/min/mg of protein)
AChE (μmoles of acetylthiocholine iodide hydrolyzed/min/mg of protein)
Normal control
0.085 ± 0.0129
1.71 ± 0.248
0.117 ± 0.0075
35.29 ± 1.64
0.0292 ± 0.0018
Vehicle control
0.074 ± 0.0070
1.87 ± 0.098
0.114 ± 0.0053
36.35 ± 2.61
0.0281 ± 0.0017
AlCl3
0.209 ± 0.0047*
3.75 ± 0.102*
0.067 ± 0.0022*
6.97 ± 0.38*
0.0141 ± 0.0014*
AlCl3 + rivastigmine
0.126 ± 0.0077#
2.32 ± 0.170#
0.104 ± 0.0031#
28.38 ± 3.18#
0.0094 ± 0.0021#
AlCl3 + simvastatin
0.125 ± 0.0225#
2.06 ± 0.073#
0.101 ± 0.0026#
24.39 ± 4.51#
0.0285 ± 0.0022#
Effect of AlCl3 and AlCl3 + treatments on frontal cortex (a) MDA, (b) nitrite level, (c) glutathione (GSH) level, (d) catalase activity, and (e) acetylcholinesterase activity. Data are presented as mean ± SEM ( = 8). * < 0.05 as compared to control group and < 0.05 as compared to AlCl3 treated group.
